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Ibuprofen and male fertility

September 25, 2018 by Brett Jones

ibuprofen-causes-male-infertility

Is Ibuprofen damaging male fertility?

(Source: Susan Scutti, CNN)

Most men have probably used Ibuprofen in their lifetimes, and some men have probably taken it hundreds of times. As an inflammatory drug that helps treat minor aches and pains – it’s used all the time and thought to be perfectly safe.

However, a recent study shows that Ibuprofen has a negative effect on the testicles of young males, and could be linked to male fertility problems. The study was published in the journal Proceedings of the National Academy of Sciences.

ibuprofen affects male fertilityWhen taking ibuprofen in doses commonly used by athletes, a small sample of young men developed a hormonal condition that typically begins, if at all, during middle age. This condition is linked to reduced fertility.

Advil and Motrin are two brand names for ibuprofen, an over-the-counter pain reliever. CNN has contacted Pfizer and Johnson & Johnson, the makers of both brands, for comment.

The Consumer Healthcare Products Association, a trade group that represents manufacturers of over-the-counter medications and supplements, “supports and encourages continued research and promotes ongoing consumer education to help ensure safe use of OTC medicines,” said Mike Tringale, a spokesman for the association. “The safety and efficacy of active ingredients in these products has been well documented and supported by decades of scientific study and real-world use.”

The new study is a continuation of research that began with pregnant women, explained Bernard Jégou, co-author and director of the Institute of Research in Environmental and Occupational Health in France.

Jégou and a team of French and Danish researchers had been exploring the health effects when a mother-to-be took any one of three mild pain relievers found in medicine chests around the globe: aspirin, acetaminophen (also known as paracetamol and sold under the brand name Tylenol) and ibuprofen.

Their early experiments, published in several papers, showed that when taken during pregnancy, all three of these mild medicines affected the testicles of male babies.

Testicles and Testosterone

Testicles not only produce sperm, they secrete testosterone, the primary male sex hormone.

All three drugs then are “anti-androgenic,” meaning they disrupt male hormones, explained David M. Kristensen, study co-author and a senior scientist in the Department of Neurology at Copenhagen University Hospital.

The three drugs even increased the likelihood that male babies would be born with congenital malformations, Kristensen noted.

Tringale noted that pregnant and nursing women should always ask a health professional before using medicines.

Knowing this, “we wondered what would happen in the adult,” he said. They focused their investigation on ibuprofen, which had the strongest effects.

A non-steroidal anti-inflammatory drug, ibuprofen is often taken by athletes, including Olympians and professional soccer players for example, before an event to prevent pain, Jégou said. Are there health consequences for the athletes who routinely use this NSAID?

The research team recruited 31 male volunteers between the ages of 18 and 35. Of these, 14 were given a daily dosage of ibuprofen that many professional and amateur athletes take: 600 milligrams twice a day, explained Jégou. (This 1200-mg-per-day dose is the maximum limit as directed by the labels of generic ibuprofen products.) The remaining 17 volunteers were given a placebo.

For the men taking ibuprofen, within 14 days, their luteinizing hormones — which are secreted by the pituitary gland and stimulate the testicles to produce testosterone — became coordinated with the level of ibuprofen circulating in their blood. At the same time, the ratio of testosterone to luteinizing hormones decreased, a sign of dysfunctional testicles.

This hormonal imbalance produced compensated hypogonadism, a condition associated with impaired fertility, depression and increased risk for cardiovascular events, including heart failure and stroke.

For the small group of young study participants who used ibuprofen for only a short time, “it is sure that these effects are reversible,” Jégou said. However, it’s unknown whether the health effects of long-term ibuprofen use are reversible, he said.

After this randomized, controlled clinical trial, the research team experimented with “little bits of human testes” provided by organ donors and then conducted test tube experiments on the endocrine cells, called Leydig and Sertoli cells, which produce testosterone, explained Jégou.

Questions around male fertility

ibuprofen linked to male fertility problemsThe World Health Organization estimates that one in every four couples of reproductive age in developing countries experiences childlessness despite five years of attempting pregnancy.

A separate study estimated that more than 45 million couples, or about 15% of all couples worldwide, were infertile in 2010, while another unrelated study suggested that men were solely responsible for up to 30% and contribute up to 50% of cases overall.

Meanwhile, a recent analysis published in the journal Human Reproduction Update found that sperm counts of men in North America, Europe, Australia and New Zealand are plunging. Researchers recorded a 52% decline in sperm concentration and a 59% decline in total sperm count over a nearly 40-year period ending in 2011.

Erma Z. Drobnis, an associate professional practice professor of reproductive medicine and fertility at the University of Missouri, Columbia, noted that most drugs are not evaluated for their effects on human male fertility before marketing. Drobnis, who was not involved in the new study, has done extensive research into sperm biology and fertility.

There is evidence that some medications are particularly harmful to the male reproductive system, including testosterone, opioids, antidepressants, antipsychotics, immune modulators and even the over-the-counter antacid cimetidine (Tagamet),” she said. “However, prescribing providers rarely mention these adverse effects with patients when prescribing these medications.

She believes the new study, though small, is “important” because ibuprofen is among the most commonly used medications.

Though the new research indicates that ibuprofen disrupts the reproductive hormones in healthy young men, she thinks it’s possible there’s an even greater negative effect in men with low fertility. The other OTC drugs concerning for potential fathers are cimetidine and acetaminophen. She recommends that men who are planning to father a child avoid drugs for several months.

“Larger clinical trials are warranted,” she said. “This is timely work that should raise awareness of medication effects on men and potentially their offspring.”

Jégou agrees that more study is needed to answer many questions, including whether ibuprofen’s effects on male hormones are seen at low doses and whether long-term effects are reversible.

“But the alarm has been raised now,” he said. “if this serves to remind people that we are really dealing with medical drugs — not with things which are not dangerous — this would be a good thing.”

Filed Under: Male Fertility Tagged With: ibuprofen and male fertility, ibuprofen male infertility, ibuprofen sexual side effects, ibuprofen side effects for men, male fertility problems

Low Sperm Count

June 1, 2017 by Brett Jones

Sperm Count – How low is too low?

If you’re experiencing problems with male fertility, you’ll no doubt find yourself wondering if you have a low sperm count. Before we address this, we must first clarify what a “normal” sperm count would be for most men.

As you can imagine, because we usually produce so many sperm – that often a high number of sperm would still be considered to be a “low sperm count”. Normal sperm densities range from 15 million to greater than 200 million sperm per milliliter of semen.

You are considered to have a low sperm count if you have fewer than 15 million sperm per milliliter or less than 39 million sperm total per ejaculate. A low sperm count is also called oligospermia (ol-ih-go-SPUR-me-uh). A complete absence of sperm is called azoospermia.

Now, this probably seems quite confusing considering that most men would have no clue how many “milliliters” of semen are in a normal ejaculation. There are 4.92 milliliters in a teaspoon, so if a man were to ejaculate 4-5 teaspoons of semen, then that would be roughly equivalent to 20-25 milliliters.

There are many reasons why a man could have a low sperm count. Some of these might be genetic, while others could be caused by a variety of outside factors.

Reasons for low sperm count:

  •   –> Pre-existing medical conditions
  •   –> Use of alcohol, tobacco, or other drugs
  •   –> Contracting mumps after puberty
  •   –> Hernia repairs or problems
  •   –> Hormone disorders
  •   –> Exposure to radiation or chemicals
  •   –> Blockage caused from infection
  •   –> Wearing tight or restrictive underwear or garments
  •   –> Injury to the groin area

Many men will have had exposure to one or more of the above problems, and this explains why a great deal of men experience male fertility issues. Other causes of male fertility include ejaculation problems, premature ejaculation, retrograde ejaculation (when semen is forced back into the bladder), erectile dysfunction, history of STD’s, urinary tract infections, and certain types of medications.

It’s important to note that if you are suffering from a low sperm count, then there is a very good chance that a semen supplement  (Semenax, Volumaxx, etc.) can make a big difference – not only in sperm count, but also for improving overall sperm health and motility. If you have a low sperm count you should consider adding a sperm pill to your supplement regime right away.

While the average man can produce large quantities of sperm multiple times per day, sometimes an internal factor, such as varicocele (enlarged veins within the scrotum), could lower the number of sperm. External factors such as smoking, drug usage, poor diet and lack of exercise can also all decrease sperm count. So as you can see, many things that we know are bad for overall health are also extremely bad for our sperm and fertility.

Low Sperm Count – Treatments and options.

If you think you may have a low sperm count, it’s important you take action as soon as possible. Of course, the first thing you should do is make an appointment with your doctor or a fertility specialist to express your concerns and see if you should be tested for low sperm count or other male fertility problems.

However there are many tips to improve sperm count that you can implement immediately even before you see a medical professional. Many of these are very simple and can be started as soon as you finish reading this page! Most of these things are free or very low cost options for boosting your sperm count.

7 Tips to raise your sperm count:

  • Take a daily semen or male fertility supplement
  • Stop tobacco or marijuana smoking
  • Reduce alcohol intake
  • Start exercising
  • Wear looser and nonrestrictive underwear
  • Reduce stress and fatigue
  • Drink more water

As you can see, there are several techniques that every man can use to boost sperm production, regardless of whether or not they have a low sperm count. Many of these tips will provide several health benefits to your body aside from making more sperm.

Getting plenty of exercise, quitting smoking, and reducing alcohol will all have a quick and positive effect on your sperm count. Getting a good night sleep and reducing stress will also have a noticeable effect. It has been shown that stress and fatigue can potentially interfere with normal sperm production.

Treatment options for men with low sperm count vary depending on the cause of the condition. For example, surgery is the most common treatment for men suffering from varicocele. Medication and hormone replacement treatment options can also be used when the cause of low sperm count is related to a hormone imbalance. A doctor-formulated sperm supplement is something that will provide noticeable benefits for ANY man – and especially men with low sperm count.

We advise men who suspect they have a low sperm count to implement the techniques listed above, and make sure you consult a physician if you think you have a serious medical issue. Low sperm count is a problem for many men, but there is much you can do about it! Reading this article was the first step – so take action and soon your little swimmers will be back at proper levels and firing on all cylinders.

 

see the top pills to increase low sperm count

 

Filed Under: Male Fertility Tagged With: low sperm count, low sperm count causes, low sperm count symptoms, low sperm count test, low sperm count treatment, male fertility problems, sperm count, sperm count range

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